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S-腺苷甲硫氨酸（SAM-e，SAMe，SAM，AdoMet，ademetionine）由GL Cantoni于1952年在意大利發(fā)現(xiàn)。它是由三磷酸腺苷（ATP）和甲硫氨酸經(jīng)甲硫氨酸腺苷轉(zhuǎn)移酶制成的。S-腺苷甲硫氨酸是大多數(shù)生物體中的關(guān)鍵代謝物。它通過脫羧作用發(fā)揮重要的轉(zhuǎn)甲基、轉(zhuǎn)硫和氨丙基化功能。
由于 SAM 是一種本質(zhì)上不穩(wěn)定的分子，其 258-260 nm 的最大光密度不是顯著的吸收，因此測定其在各種生物體液和組織中的濃度一直是一項(xiàng)具有挑戰(zhàn)性的任務(wù)。一種不需要昂貴儀器（LC、MS 和組合）的簡單、方便的方法顯然是確定 SAM 的生物濃度以及監(jiān)測其在體液、組織和細(xì)胞器中的變化和代謝路徑的理想選擇。
據(jù)稱 SAM-e 有助于以下疾病：抑郁癥、帕金森病、骨關(guān)節(jié)炎癥狀、肝病、肝內(nèi)膽汁淤積癥（尤其是妊娠期）、纖維肌痛、艾滋病相關(guān)的脊髓?。ㄅc艾滋病相關(guān)的脊柱和神經(jīng)疾?。?/span>也有有限的研究參考了 SAMe 在以下情況中的作用：注意力缺陷多動(dòng)障礙 (ADHD)、經(jīng)前期綜合征 (PMS)、經(jīng)前期煩躁癥 (PMDD)、慢性疲勞綜合征 (CFS)、心臟病、智力缺陷表現(xiàn)、多發(fā)性硬化、癡呆、阿爾茨海默病、肌腱炎、滑囊炎、脊髓損傷、癲癇發(fā)作、偏頭痛、慢性腰痛、鉛中毒和衰老。
如今，當(dāng) SAM 每天用作營養(yǎng)補(bǔ)充劑時(shí)，了解其影響和后果也是至關(guān)重要的。它已被廣泛用作非處方藥，以緩解抑郁癥、骨關(guān)節(jié)炎等系統(tǒng)。
Arthus Biosystems 很高興提供一系列研究試劑和試劑盒，以幫助開展與蛋氨酸循環(huán)相關(guān)的科學(xué)研究，蛋氨酸循環(huán)是所有生物體進(jìn)化過程中保守的關(guān)鍵生化途徑。我們的 SAM 和 SAH 單克隆抗體具有非常高的滴度和親和力，讓您只需一瓶即可完成大部分研究。迄今為止，我們的抗 SAM 和 SAH 抗體均具有*佳靈敏度。我們還提供經(jīng)過驗(yàn)證的 SAM 和 SAH 偶聯(lián)物以及生物s等示蹤分子，以幫助您研究生物分子-生物分子的相互作用并開發(fā)進(jìn)一步的檢測方法。
上海起發(fā)arthusbio2022年產(chǎn)品目錄
| Catalog No. | Name | Description | Packaging |
|---|---|---|---|
| Immunoassay Kits and Strips | |||
| IK00201 | SAM ELISA | S-adenosylmethionine ELISA kit | 96 tests |
| IK00201s | SAM ELISA s | S-adenosylmethionine ELISA kit for plasma, serum, or tissue/cell homogenate samples | 96 tests |
| IK00202 | SAM ELISA 2 | S-adenosylmethionine ELISA kit, broad range | 96 tests |
| IK00202s | SAM ELISA 2s | S-adenosylmethionine ELISA kit for plasma, serum, or tissue/cell homogenate samples, broad range | 96 tests |
| IK00203 | SAM ELISA 3 | S-adenosylmethionine ELISA kit, broad range | 48 tests |
| IK00203s | SAM ELISA 3s | S-adenosylmethionine ELISA kit for plasma, serum, or tissue/cell homogenate samples, broad range | 48 tests |
| IK00204 | SAM ELISA 4 | S-adenosylmethionine ELISA kit for cell culture supernatant or other samples | 96 tests |
| IK00301 | SAH ELISA | S-adenosylhomocysteine ELISA kit | 96 tests |
| IK00301s | SAH ELISA s | S-adenosylhomocysteine ELISA kit for plasma, serum, or tissue/cell homogenate samples | 96 tests |
| IK00302 | SAH ELISA 2 | S-adenosylhomocysteine ELISA kit, broad range | 96 tests |
| IK00302s | SAH ELISA 2s | S-adenosylhomocysteine ELISA kit for plasma, serum, or tissue/cell homogenate samples, broad range | 96 tests |
| IK00303 | SAH ELISA 3 | S-adenosylhomocysteine ELISA kit, broad range | 48 tests |
| IK00303s | SAH ELISA 3s | S-adenosylhomocysteine ELISA kit for plasma, serum, or tissue/cell homogenate samples, broad range | 48 tests |
| IK00304 | SAH ELISA 4 | S-adenosylhomocysteine ELISA kit for cell culture supernatant or other samples | 96 tests |
| IK00401 | MAT Activity Assay | Methionine Adenosyltransferase (MAT) activity assay kit | 96 tests |
| IK00403 | MAT Activity Assay 3 | Methionine Adenosyltransferase (MAT) activity assay kit | 48 tests |
| Antibodies and Conjugates | |||
| MA00201-50 | Mouse anti-SAM 1b | Mouse monoclonal antibody to S- denosylmethionine Clone 118-6 | 100µg |
| MA00201-100 | Mouse anti-SAM 1a | Mouse monoclonal antibody to S-Adenosylmethionine Clone 118-6 | 50µg |
| MA00202-50 | Mouse anti-SAM 2a | Mouse monoclonal antibody to S- denosylmethionine Clone 84-3 | 50µg |
| MA00202-100 | Mouse anti-SAM 2b | Mouse monoclonal antibody to S-Adenosylmethionine Clone 84-3 | 100µg |
| MA00203-50 | Mouse anti-SAM 3a | Mouse monoclonal antibody to S-Adenosylmethionine Clone 118-18 | 50µg |
| MA00204-50 | Mouse anti-SAM 4a | Mouse monoclonal antibody to S-Adenosylmethionine Clone 84-19 | 50µg |
| PA00201-50 | Rabbit anti-SAM a | Rabbit polyclonal antibody to S-Adenosylmethionine | 50µg |
| PA00201-100 | Rabbit anti-SAM b | Rabbit polyclonal antibody to S-Adenosylmethionine | 100µg |
| MA00301-50 | Mouse anti-SAH 1a | Mouse monoclonal antibody to S-Adenosylhomocysteine Clone 301-1 | 50µg |
| MA00302-50 | Mouse anti-SAH 2a | Mouse monoclonal antibody to S-Adenosylhomocysteine Clone 301-10 | 50µg |
| MA00303-50 | Mouse anti-SAH 3a | Mouse monoclonal antibody to S-Adenosylhomocysteine Clone 301-3 | 50µg |
| MA00304-50 | Mouse anti-SAH 4a | Mouse monoclonal antibody to S-Adenosylhomocysteine Clone 301-16 | 50µg |
| MA00305-50 | Mouse anti-SAH 5a | Mouse monoclonal antibody to S-Adenosylhomocysteine Clone 844-1 | 50µg |
| MA00306-50 | Mouse anti-SAH 6a | Mouse monoclonal antibody to S-Adenosylhomocysteine Clone 844-2 | 50µg |
| MA00307-50 | Mouse anti-SAH 7a | Mouse monoclonal antibody to S-Adenosylhomocysteine Clone 839-6 | 50µg |
| MA00308-50 | Mouse anti-SAH 8a | Mouse monoclonal antibody to S-Adenosylhomocysteine Clone 839-12 | 50µg |
| MAF00201-25 | AF6-anti-SAM 1a | Alexa Fluor® 647 (AF6) conjugated anti-SAM monoclonal antibody Clone 118-6 | 25µg |
| MAF00201-50 | AF6-anti-SAM 1b | Alexa Fluor® 647 (AF6) conjugated anti-SAM monoclonal antibody Clone 118-6 | 50µg |
| MAF00202-50 | AF6-anti-SAM 2a | Phycoerythrin (PE) conjugated anti-SAM monoclonal antibody Clone 84-3 | 50µg |
| MAF00301-25 | AF488-anti-SAH 1a | Alexa Fluor® 488 (AF488) conjugated anti-SAH monoclonal antibody Clone 301-3 | 25µg |
| MAF00301-50 | AF488-anti-SAH 1b | Alexa Fluor® 488 (AF488) conjugated anti-SAH monoclonal antibody Clone 301-3 | 50µg |
| MAF00302-50 | AF488-anti-SAH 2a | Alexa Fluor® 488 (AF488) conjugated anti-SAH monoclonal antibody Clone 839-6 | 50µg |
| MAH00201-50 | HRP-anti-SAM 1a | Horseradish peroxidase (HRP) conjugated anti-SAM monoclonal antibody Clone 118-6 | 50µl |
| MAH00202-50 | HRP-anti-SAM 2a | Horseradish peroxidase (HRP) conjugated anti-SAM monoclonal antibody Clone 84-3 | 50µl |
| MAH00203-50 | HRP-anti-SAM 3a | Horseradish peroxidase (HRP) conjugated anti-SAM monoclonal antibody Clone 118-18 | 50µl |
| MAH00204-50 | HRP-anti-SAM 4a | Horseradish peroxidase (HRP) conjugated anti-SAM monoclonal antibody Clone 84-19 | 50µl |
| MAH00301-50 | HRP-anti-SAH 1a | Horseradish peroxidase (HRP) conjugated anti-SAH monoclonal antibody Clone 301-3 | 50µl |
| MAH00302-50 | HRP-anti-SAH 2a | Horseradish peroxidase (HRP) conjugated anti-SAH monoclonal antibody Clone 301-16 | 50µl |
| MAH00701-50 | HRP-anti-DIG | Peroxidase-conjugated IgG Fraction Monoclonal Mouse Anti-Digoxigenin | 50µl |
| PA00401-50 | Rabbit anti-MAT s | Rabbit polyclonal antiserum against methionine adenosyltransferase | 50µl |
| PA00401-50 | Rabbit anti-MAT g | Rabbit polyclonal antiserum against methionine adenosyltransferase (with glycerol) | 50µl |
| Compounds and Conjugates | |||
| AST00201 | Aza-SAM | A series of S-adenosylmethionine analog Aza-SAM standards: 500nM, 250nM, 125nM, 62.5nM, 31.25nM, 15.625nM, 7.8125nM, 0nM | 1ml |
| AST00201-1 | Aza-SAM a | S-adenosylmethionine analog Aza-SAM standard. Buffer (4 ml) for serial dilution may be supplied (additional $15 each). | 1ml (500nM) |
| AST00201-200 | Aza-SAM b | S-adenosylmethionine analog Aza-SAM standard. Buffer (10 ml) for serial dilution may be supplied (additional $15 each). | 200ul (5µM) |
| AST00201-1s | Aza-SAM as | S-adenosylmethionine analog Aza-SAM standard for serum/plasma. Buffer (3.2 ml) for serial dilution may be supplied. | 1ml (1µM) |
| ACT00201-5 | PLL-aza-SAM a | Poly-lysine was conjugated to S-adenosylmethionine analog Aza-SAM (AST00201). Coating for 10-20 96-well micro-titer plates. | 5µg |
| ACT00201-10 | PLL-aza-SAM b | Poly-lysine was conjugated to S-adenosylmethionine analog Aza-SAM (AST00201). Coating for 20-40 96-well micro-titer plates. | 10µg |
| ACT00202-50 | Bio-SAM a | Biotin is conjugated to NH2 group of S-adenosylmethionine. | 50µg |
| ACT00202-100 | Bio-SAM b | Biotin is conjugated to NH2 group of S-adenosylmethionine. | 100µg |
| ACT00203-50 | Bio-6C-SAM 1a | Biotin is conjugated to NH2 of SAM through 6-aminohexanoic acid. | 50µg |
| ACT00203-100 | Bio-6C-SAM 1b | Biotin is conjugated to NH2 of SAM through 6-aminohexanoic acid. | 100µg |
| ACT00204-5 | BSA-aza-SAM a | Bovine serum Albumin was conjugated to S-adenosylmethionine analog Aza-SAM (AST00201). Coating for 10-20 96-well micro-titer plates. | 5µg |
| ACT00205-10 | Bio-6C-aza-SAM 1a | Biotin is conjugated to the NH2 of aza-SAM through 6-aminohexanoic acid. | 10µg |
| ACT00205-50 | Bio-6C-aza-SAM 1b | Biotin is conjugated to the NH2 of aza-SAM through 6-aminohexanoic acid. | 50µg |
| ACT00205-100 | Bio-6C-aza-SAM 1c | Biotin is conjugated to the NH2 of aza-SAM through 6-aminohexanoic acid. | 100µg |
| ACT00206-10 | Bio-12CN-aza-SAM 1a | Biotin is conjugated to the NH2 of aza-SAM through a 10-carbon and 2-nitrogen linker. | 10µg |
| ACT00206-50 | Bio-12CN-aza-SAM 1b | Biotin is conjugated to the NH2 of aza-SAM through a 10-carbon and 2-nitrogen linker. | 50µg |
| ACT00206-100 | Bio-12CN-aza-SAM 1c | Biotin is conjugated to the NH2 of aza-SAM through a 10-carbon and 2-nitrogen linker. | 100µg |
| AST00301-1 | SAH-Na | S-Adenosylhomocysteine standard ( SAH Sodium). Buffer (18 ml) for serial dilution may be supplied (additional $15 each). | 1ml (4µM) |
| AST00301-1s | SAH-Na s | S-Adenosylhomocysteine standard ( SAH Sodium) for serum/plasma. Buffer (8ml) for serial dilution may be supplied (additional $60 each). | 0.5ml (4µM) |
| ACT00301-50 | BSA-SAH | BSA was conjugated to S-Adenosylhomocysteine. Coating for 10 96-well micro-titer plates. | 50µg (20µg) |
| ACT00302-50 | Bio-SAH a | Biotin is conjugated to NH2 group of S-adenosylhomocysteine. | 50µg |
| ACT00302-100 | Bio-SAH b | Biotin is conjugated to NH2 group of S-adenosylhomocysteine. | 100µg |
| ACT00303-50 | Bio-6C-SAH 1a | Biotin is conjugated to NH2 of SAH through 6-aminohexanoic acid. | 50µg |
| ACT00303-100 | Bio-6C-SAH 1b | Biotin is conjugated to NH2 of SAH through 6-aminohexanoic acid. | 100µg |
| ACT00304-25 | Dig-6C-SAH 1a | Digoxin is conjugated to NH2- of SAH through 6-bromocaproic acid | 25µg |
| ACT00304-50 | Dig-6C-SAH 1b | Digoxin is conjugated to NH2 of SAH through 6-bromocaproic acid. | 50µg |
| ACT00304-100 | Dig-6C-SAH 1c | Digoxin is conjugated to NH2 of SAH through 6-bromocaproic acid. | 100µg |
| ACT00305-10 | Bio-12CN-SAH 1a | Biotin is conjugated to NH2 of SAH through a 10-carbon and 2-nitrogen linker. | 10µg |
| ACT00305-50 | Bio-12CN-SAH 1b | Biotin is conjugated to NH2 of SAH through a 10-carbon and 2-nitrogen linker. | 50µg |
| ACT00305-100 | Bio-12CN-SAH 1c | Biotin is conjugated to NH2 of SAH through a 10-carbon and 2-nitrogen linker. | 100µg |
| AST00401-50 | MAT a | Recombinant methionine adenosyltransferase (E.C. 2.5.1.6), E. Coli expression | 50µg |
| AST00401-500 | MAT b | Recombinant methionine adenosyltransferase (E.C. 2.5.1.6), E. Coli expression | 500µg |
| ACT00501-100 | BSA-HCY | Bovine serum albumin (BSA) was conjugated to homocysteine (HCY). | 100µg |
| AST00601-50 | HMT a | Recombinant Homocysteine S-methyltransferase (E.C. 2.1.1.10), E. Coli expression | 50µg |
| AST00601-500 | HMT b | Recombinant Homocysteine S-methyltransferase (E.C. 2.1.1.10), E. Coli expression | 500µg |
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